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KMID : 1024520020110040391
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Journal of the Environmental Sciences
2002 Volume.11 No. 4 p.391 ~ p.397
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Inhibition of Cholinesterase Activity by Carbamate Insecticides
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Kim Jung-Ho
Park Heung-Jai
Park Byoung-Yoon
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Abstract
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This study was carried out with the inhibition of the cholinesterase activity by carbamate insecticides in the chicken in vivo and in vitro. The optimum pH of cholinesterase was 8.0. The cholinesterase activity used the acetylcholin as substrate in plasma was 24.6 mol/min/g protein. After oral administration with 0.32 mg/kg of BPMC as carbamate pesticide, the cholinesterase activity was inhibited to 60% of control after 15min in vivo. Then the recovery of cholinesterase activity followed to 97% of control after 12hr. I, such as concentration required for 50% inhibition of enzyme activity, of phenyl N-methylcarbamate were 329 / of XMC, 214 / of metolcarb, 111 / of BPMC, 107 / of propoxur and 104 / of isoprocarb. I of aromatic N-methylcarbamate were 280 / of carbaryl and 114 / carbofuran.ran.
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KEYWORD
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cholinesterase, carbamate inseticide, XMC, metolcarb, BPMC, propoxur, isoprocarb, carbaryl, carbofuran, enzyme-inhibition
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